A national cancer control plan (NCCP) is a strategic plan that aims to reduce cancer incidence and mortality and improve quality of life by using evidence-based interventions to maximize a country’s healthcare resources. NCCPs are essential tools in the global effort to manage the growing burden of noncommunicable diseases. Oncology nurses must understand and participate in the process of NCCP development and implementation to ensure that proposed interventions are acceptable to the target population and that training needs of the healthcare workforce are appropriately addressed, and to effectively deliver interventions from teaching cancer prevention behaviors to administering end-of-life care.