Herbs or Natural Products That Increase Cancer Growth or Recurrence: Part Two of a Four-Part Series

Muriel J. Montbriand

ONF 2004, 31(5), E99-E115. DOI: 10.1188/04.ONF.E99-E115

Purpose/Objectives: To review 32 herbs and natural products that show potential to increase cancer growth or recurrence or to interfere with cancer treatments.

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    Agerbaek, M., Gerdes, L.U., & Richelsen, B. (1995). Hypocholesterolaemic effects of a new fermented milk product in healthy middle-aged men. European Journal of Clinical Nutrition, 49, 346-352.

    Agus, D.B., Vera, J.C., & Golde, D.W. (1999). Stromal cell oxidation: A mechanism by which tumors obtain vitamin C. Cancer Research, 59, 4555-4558.

    American Cancer Society 1996 Advisory Committee on Diet, Nutrition, and Cancer Prevention. (1996). Guidelines on diet, nutrition, and cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity. CA: A Cancer Journal for Clinicians, 46, 325-341.

    Bisset, N.G., & Wichtl, M. (Eds.). (1994). Herbal drugs and phytopharmaceuticals. A handbook for practice on a scientific basis. London: Medpharm.

    Blumenthal, M., Busse, W.R., Goldberg, A., Gruenwald, J., Hall, T., Riggins, C.W., et al. (Eds.). (1998). The complete German commission E monographs: Therapeutic guide to herbal medicines (S. Klein, Trans.). Boston: American Botanical Council.

    Blumenthal, R.D., Lew, W., Reising, A., Soyne, D., Osorio, L., Ying, Z., et al. (2000). Anti-oxidant vitamins reduce normal tissue toxicity induced by radio-immunotherapy. International Journal of Cancer, 86, 276-280.

    Brinker, F. (1998). Herb contraindications and drug interactions (2nd ed.). Sandy, OR: Eclectic Medical.

    Broeder, C.E., Quindry, J., Brittingham, K., Panton, L., Thomson, J., Appakondu, S., et al. (2000). The Andro project: Physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Archives of Internal Medicine, 160, 3093-3104.

    Brown, D. (1994). Vitex agnus castus clinical monograph. Quarterly Review of Natural Medicine, 2(2), 111-129.

    Brown, G.A., Vukovich, M.D., Martini, E.R., Kohut, M.L., Franke, W.D., Jackson, D.A., et al. (2000). Endocrine responses to chronic androstenedione intake in 30- to 56-year-old men. Journal of Clinical Endocrinology and Metabolism, 85, 4074-4080.

    Brown, R. (1997). Potential interactions of herbal medicines with anti-psychotics, antidepressants and hypnotics. European Journal of Herbal Medicine, 3, 25-28.

    Carbo, N., Costelli, P., Baccino, F.M., Lopez-Soriano, F.J., & Argiles, J.M. (1999). Resveratrol, a natural product in wine, decreases tumor growth in a rat tumour model. Biochemical and Biophysical Research Communications, 254, 739-743.

    Cheng, T.O. (2000). Ginseng-warfarin interaction. ACC Current Journal Review, 9, 84.

    Chlebowski, R.T., Bulcavage, L., Grosvenor, M., Tsunokai, R., Block, J.B., Heber, D., et al. (1987). Hydrazine sulfate in cancer patients with weight loss. A placebo-controlled clinical experience. Cancer, 59, 406-410.

    Dehydroepiandrosterone (DHEA). (1996). Medical Letter on Drugs and Therapeutics, 38, 91-92.

    Devlin, T.M. (Ed.). (1992). Textbook of biochemistry with clinical correlations (3rd ed.). New York: Wiley-Liss.

    De Vrese, M., Keller, B., & Barth, C.A. (1992). Enhancement of intestinal hydrolysis of lactose by microbial beta-galactosidase (EC of kefir. British Journal of Nutrition, 67(1), 67-75.

    Drovanti, A., Bignamini, A.A., & Rovati, A.A. (1980). Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: A placebo-controlled, double-blind investigation. Clinical Therapeutics, 3, 260-272.

    Duda, R.B., Zhong, Y., Navas, V., Li, M.Z., Toy, B.R., & Alavarez, J.G. (1999). American ginseng and breast cancer therapeutic agents synergistically inhibit MCF-7 breast cancer growth. Journal of Surgical Oncology, 72, 230-239.

    Eagon, P.K., Elm, M.S., & Hunter, D.S. (2000, June). Medicinal herbs: Modulation of estrogen action. Paper presented at the Era of Hope Meeting for the Department of Defense Breast Cancer Research Program, Atlanta, GA.

    Ellenhorn, M.J., & Barceloux, D.G. (1997). Ellenhorn's medical toxicology: Diagnoses and treatment of human poisoning (2nd ed.). Baltimore: Williams and Wilkins.

    El-Nezami, H., Kankaanpaa, P., Salminen, S., & Ahokas, J. (1998). Ability of dairy strains of lactic acid bacteria to bind a common food carcinogen, aftatoxin B1. Food and Chemical Toxicology, 36, 321-326.

    Ernst, E. (2000a). Prevalence of use of complementary/alternative medicine: A systematic review. Bulletin of the World Health Organization, 78, 252-257.

    Ernst, E. (2000b). The role of complementary and alternative medicine in cancer. Lancet Oncology, 1(3), 176-180.

    Ernst, E., & Cassileth, B.R. (1998). The prevalence of complementary/alternative medicine in cancer: A systematic review. Cancer, 83, 777-782.

    Evans, B.A., Griffiths, K., & Morton, M.S. (1995). Inhibition of 5 alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. Journal of Endocrinology, 147, 295-302.

    Facts and Comparisons. (2001). The Lawrence review of natural products-monograph system. St. Louis, MO: Walter Kluwer.

    Ferenci, P., Dragosics, B., Dittrich, H., Frank, H., Benda, L., Lochs, H., et al. (1989). Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. Journal of Hepatology, 9, 105-113.

    Fetrow, C.W., & Avila, J.R. (1999). Professional's handbook of complementary and alternative medicines. Springhouse, PA: Springhouse.

    Foster, S. (1999). Black cohosh (Cimicifuga racemosa): A literature review. Herbalgram, 45(Winter), 35-49.

    Foster, S., & Tyler, V.E. (1999). Tyler's honest herbal: A sensible guide to the use of herbs and related remedies (4th ed.). Binghamton, NY: Haworth Herbal Press.

    Freeman, E.W., Weinstock, L., Rickels, K., Sondheimer, S.J., & Coutifaris, C. (1992). A placebo-controlled study of effects of oral progesterone on performance and mood. British Journal of Clinical Pharmacology, 33, 293-298.

    Gehm, B.D., McAndrews, J.M., Chien, P.Y., & Jameson, J.L. (1997). Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proceedings of the National Academy of Science, 94, 14138-14143.

    Goldin, B.R. (1998). Health benefits of probiotics. British Journal of Nutrition, 80, S203-S207.

    Goldin, B.R., Gualtieri, L.J., & Moore, R.P. (1996). The effect of lactobacillus GG on the initiation and promotion of DMH-induced intestinal tumors in the rat. Nutrition and Cancer, 25, 197-204.

    Green, N.R., & Ferrando, A.A. (1994). Plasma boron and the effects of boron supplementation in males. Environmental Health Perspectives, 102(Suppl. 7), 73-77.

    Greenspan, E.M. (1983). Ginseng and vaginal bleeding. JAMA, 249, 2018.

    Gruenwald, J. (1998). Standardized black cohosh (Cimicifuga) extract clinical monograph. Quarterly Review of Natural Medicine, 3, 117-125.

    Gruenwald, J., Brendler, T., & Jaenicke, C. (Eds.). (1998). PDR® for herbal medicines. Montvale, NJ: Medical Economics.

    Haggans, C.J., Hutchins, A.M., Olson, B.A., Thomas, W., Martini, M.C., & Slavin, J.L. (1999). Effect of flaxseed consumption on urinary estrogen metabolites in postmenopasual women. Nutrition and Cancer, 33, 188-195.

    Hakkak, R., Korourian, S., Shelnutt, S.R., Lensing, S., Ronis, M.J., & Badger, T.M. (2000). Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats. Cancer Epidemiology, Biomarkers and Prevention, 9, 113-117.

    Hansten, P.D., & Horn, J.R. (1997). Drug interactions: Analysis and management. Vancouver, WA: Applied Therapeutics.

    Health and Welfare Canada. (1990). Nutrition recommendations. Ottawa, Canada: Canadian Government Publishing Centre.

    Health Canada, Part II: Regulation and Regulatory Structure. (2002). Health Canada site on natural health products. Retrieved April 4, 2002, from http://www.hc-sc.gc.ca/hpb/onhp/welcome_e.html

    Hegarty, V.M., May, H.M., & Khaw, K. (2000). Tea drinking and bone density in older women. American Journal of Clinical Nutrition, 71, 1003-1007.

    Hopkins, M.P., Androff, L., & Benninghoff, H.S. (1988). Ginseng face cream and unexplained vaginal bleeding. American Journal of Obstetrics and Gynecology, 159, 1121-1122.

    Huang, K.C. (1999). The pharmacology of Chinese herbs (2nd ed.). Boca Raton, FL: CRC Press.

    Israel, K., Yu, W., Sanders, B.G., & Kline, K. (2000). Vitamin E succinate induces apoptosis in human prostate cancer succinate-triggered apoptosis. Nutrition and Cancer, 36, 90-100.

    Jacobsen, B.K., Knutsen, S.F., & Fraser, G.E. (1998). Does high soy milk intake reduce prostate cancer incidence? Cancer Causes and Control, 9, 553-557.

    Janetzky, K., & Morreale, A.P. (1997). Probable interaction between warfarin and ginseng. American Journal of Health-System Pharmacy, 54, 692-693.

    Jang, M., Cai, L., Udeani, G.O., Slowing, K.V., Thomas, C.F., Beecher, C.W., et al. (1997). Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science, 275, 218-220.

    Jolliet, P., Simon, N., Barre, J., Pons, J.Y., Boukef, M., Paniel, B.J., et al. (1998). Plasma coenzyme Q10 concentrations in breast cancer: Prognosis and therapeutic consequences. International Journal of Clinical Pharmacology Therapy, 36, 506-509.

    Kaegi, E. (1998). Unconventional therapies for cancer: 4. Hydrazine sulfate. Task force on alternative therapies of the Canadian Breast Cancer Research Initiative. Journal of the Canadian Medical Association, 158, 1327-1330.

    Kalima, P., Masterton, R.G., Roddie, P.H., & Thomas, A.E. (1996). Lacto-bacillus rhamnosus infection in a child following bone marrow transplant. Journal of Infectious Diseases, 32, 165-167.

    King, D.S., Sharp, R.L., Vukovich, M.D., Brown, G.A., Reifenrath, T.A., Uhl, N.L., et al. (1999). Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: A randomized controlled trial. JAMA, 281, 2020-2028.

    Kosty, M.P., Fleishman, S.B., Herndon, J.E., II, Coughlin, K., Kornblith, A.B., Scalzo, A., et al. (1994). Cisplatin, vinblastine, and hydrazine sulfate in advanced, non-small-cell lung cancer: A randomized, placebo-controlled, double-blind phase III study of the cancer and leukemia group B. Journal of Clinical Oncology, 12, 1113-1120.

    Kroboth, P.D., Salek, F.S., Pittenger, A.L., Fabian, T.J., & Frye, R.F. (1999). DHEA and DHEA-S: A review. Journal of Clinical Pharmacology, 39, 327-348.

    Kuritzky, L. (1998). DHEA: Science or wishful thinking? Hospital Practice, 33, 85-86.

    Kurzer, M.S., & Xu, X. (1997). Dietary phytoestrogens. Annual Review of Nutrition, 17, 353-381.

    Lampe, J.W., Martini, M.C., Kurzer, M.S., Adlercreutz, H., & Slavin, J.L. (1994). Urinary lignan and isoflavonoid excretion in premenopausal women consuming flaxseed powder. American Journal of Clinical Nutrition, 60, 122-128.

    Langsjoen, P.H., Langsjoen, P.H., & Folkers, K. (1990). Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. American Journal of Cardiology, 15, 521-523.

    Le Bail, J.C., Champavier, Y., Chulia, A.J., & Habrioux, G. (2000). Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. Life Science, 66, 1281-1291.

    Leder, B.Z., Longcope, C., Catlin, D.H., Ahrens, B., Schoenfeld, D.A., & Finkelstein, J.S. (2000). Oral androstenedione administration and serum testosterone concentrations in young men. JAMA, 283, 779-782.

    Leung, A.Y., & Foster, S. (1996). Encyclopedia of common natural ingredients used in food, drugs, and cosmetics (2nd ed.). New York: John Wiley and Sons.

    Liede, K.E., Haukka, J.K., Saxen, L.M., & Heinonen, O.P. (1998). Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Annals of Medicine, 30, 542-546.

    Liske, E. (1998). Therapeutic efficacy and safety of Cimicifuga racemosa for gynecologic disorders. Advanced Therapy, 15(1), 45-53.

    Lopes Vaz, A.L. (1982). Double-blind, clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Current Medical Research and Opinion, 8, 145-149.

    Loprinzi, C.L., Goldberg, R.M., & Burnham, N.L. (1992). Cancer-associated anorexia and cachexia. Implications for drug therapy. Drugs, 43, 499-506.

    Lund, E.L., Quistorff, B., Spang-Thomsen, M., & Kristjansen, P.E. (1998). Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake. Folia Microbiologica, 43, 505-506.

    Malinow, M.R., Bardana, E.J., & Goodnight, S.H., Jr. (1981). Pancytopenia during ingestion of alfalfa seeds. Lancet, 1(8220, Pt. 1), 615.

    Martindale, W. (1999). Martindale: The extra pharmacopoeia. London: Royal Pharmaceutical Society, Pharmaceutical Press.

    Massey, L.K., Palmer, R.G., & Horner, H.T. (2001). Oxalate content of soybean seeds (Glycine max: Leguminosae), soyfoods, and other edible legumes. Journal of Agricultural and Food Chemistry, 49, 4262-4266.

    McCaleb, R.S., Leigh, E., & Morien, K. (2000). The encyclopedia of popular herbs. Roseville, CA: Prima Health.

    McFarlin, B.L., Gibson, M.H., O'Rear, J., & Harman, P. (1999). A national survey of herbal preparation use by nurse-midwives for labor stimulation. Review of the literature and recommendations for practice. Journal of Nurse Midwifery, 44, 205-216.

    McGuffin, M., Hobbs, C., Upton, R., & Goldberg, A. (1997). American Herbal Products Association's botanical safety handbook. Boca Raton, FL: CRC Press.

    McIntosh, G.H., Royle, P.J., & Playne, M.J. (1999). A probiotic strain of L acidophilus reduces DMH-induced large intestinal tumors in male Sprague-Dawley rats. Nutrition and Cancer, 25, 197-204.

    McKevoy, G.K. (Ed.). (1998). AHFS drug information. Bethesda, MD: American Society of Health-System Pharmacists.

    McMichael-Phillips, D.F., Harding, C., Morton, M., Roberts, S.A., Howell, A., Potten, C.S., et al. (1998). Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast. American Journal of Clinical Nutrition, 68(6, Suppl.), 1431S-1435S.

    Merz, P.G., Gorkow, C., Schrodter, A., Rietbrock, S., Sieder, C., Loew, D., et al. (1996). The effects of a special agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects. Experimental and Clinical Endocrinology and Diabetes, 104, 447-453.

    Micromedex Inc. (2002). Micromedex healthcare series. Englewood, CO: Author.

    Mills, S., & Bone, K. (2000). Principles and practice of phytotherapy. London: Churchill Livingstone.

    Montbriand, M.J. (1994a). Decision heuristics of patients with cancer: Alternate and biomedical choices. Unpublished doctoral dissertation, University of Saskatchewan, Saskatoon, Canada.

    Montbriand, M.J. (1994b). An overview of alternate therapies chosen by patients with cancer. Oncology Nursing Forum, 21, 1547-1554.

    Montbriand, M.J. (1995a). Alternative therapies as control behaviors used by cancer patients. Journal of Advanced Nursing, 22, 646-654.

    Montbriand, M.J. (1995b). Decision tree model describing alternate health care choices made by oncology patients. Cancer Nursing, 18, 104-117.

    Montbriand, M.J. (1997). Empowerment of seniors through improved communication about medication. In L.F. Heumann (Ed.)Proceedings of the Sixth International Conference on Systems Science in Health-Social Services for the Elderly and the Disabled (pp. 258-264). Chicago, IL: University of Illinois at Urbana-Champaign.

    Montbriand, M.J. (2000a). Health professionals' attitudes about alternative therapies. Canadian Nurse, 96, 22-26.

    Montbriand, M.J. (2000b). Senior and health-professionals' mismatched perceptions and communication about prescription and non-prescription medication. Canadian Journal on Aging, 19, 35-56.

    Montbriand, M.J. (2004). Herbs or natural products that decrease cancer growth. Part one of a four-part series. Oncology Nursing Forum, 31, E75-E90.

    Murofushi, M., Mizuguchi, J., Aibara, K., & Matuhasi, T. (1986). Immunopotentiative effect of polysaccharide from kefir grain, KGF-C, administered orally in mice. Immunopharmacology, 12(1), 29-35.

    Natural Medicines Comprehensive Database. (2003). Therapeutic Research Faculty National Database [Data file]. Available at http://www.naturaldatabase.com

    NBA bans androstenedione. (2000). Retrieved March 31, 2000, from http://nba.com/news/nba_androban_000330.html

    Newall, C.A., Anderson, L.A., & Philpson, J.D. (1996). Herbal medicine: A guide for health care professionals. London: Pharmaceutical Press.

    Newnham, R.E. (1994). Essentiality of boron for healthy bones and joints. Environmental Health Perspectives, 102(Suppl. 7), 83-85.

    Oelkers, W. (1999). Dehydroepiandosterone for adrenal insufficiency [Editorial]. New England Journal of Medicine, 341, 1073-1074.

    Office of Nutrition Policy and Promotion. (2004). Canada's food guide to healthy eating. Retrieved July 20, 2004, from http://www.hc-sc.gc.ca/hpfb-dgpsa/onpp-bppn/food_guide_rainbow_e.html

    Palmer, B.V., Montgomery, A.C., & Monteiro, J.C. (1978). Gin seng and mastalgia. BMJ, 1, 1284.

    Pelto, L., Isolauri, E., Lilius, E.M., Nuutila, J., & Salminen, S. (1998). Pro-biotic bacteria down-regulate the milk-induced inflammatory response in milk-hypersensitive subjects but have an immunostimulatory effect in healthy subjects. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology, 12, 1473-1479.

    Penland, J.G. (1994). Dietary boron, brain function, and cognitive performance. Environmental Health Perspectives, 102(Suppl. 7), 65-72.

    Pepping, J. (1999). Black cohosh: Cimicifuga racemosa. American Journal of System Pharmacists, 56, 1400-1402.

    Perlman, A.I., Eisenberg, D.M., & Panush, R.S. (1999). Talking with patients about alternative and complementary medicine. Rheumatic Disease Clinics of North America, 25, 815-822.

    Permanetter, B., Rossy, W., Klein, G., Weingartner, F., Seidl, K.F., & Blomer, H. (1992). Ubiguinone (coenzyme Q10) in the long-term treatment of idiopathic dilated cardiomyopathy. European Heart Journal, 13, 1528-1533.

    Petrakis, N.L., Barnes, S., King, E.B., Lowenstein, J., Wiencke, J., Lee, M.M., et al. (1996). Stimulatory influence of soy protein isolate on breast secretion in pre- and postmenopausal women. Cancer Epidemiology, Biomarkers and Prevention, 5, 785-794.

    Pheatt, N. (Ed.). (1999). Sport's Supplements. Pharmacist's Letter Continuing Education Booklet, 99, 1-56.

    Portakal, O., Ozkaya, O., Erden Inal, M., Bozan, B., Kosan, M., & Sayek, I. (2000). Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clinical Biochemistry, 33, 279-284.

    Questionable methods of cancer management: Nutritional therapies. (1993). CA: A Cancer Journal for Clinicians, 43, 309-319.

    Rasmussen, B.B., Volpi, E., Gore, D.C., & Wolfe, R.R. (2000). Androstenedione does not stimulate muscle anabolism in young healthy men. Journal of Clinical Endocrinology and Metabolism, 85(1), 55-59.

    Richelsen, B., Kristensen, K., & Pedersen, S.B. (1996). Long-term (6 months) effect of a new fermented milk product on the level of plasma lipoproteins—A placebo-controlled and double-blind study. European Journal of Clinical Nutrition, 50, 811-815.

    Rimada, P.S., & Abraham, A.G. (2001). Polysaccharide production by kefir grains during whey fermentation. Journal of Dairy Research, 68, 653-661.

    Robbers, J.E., Speedie, M.K., & Tyler, V.E. (1996). Pharmacognosy and pharmacobiotechnology. Baltimore: Williams and Wilkins.

    Saxelin, M., Chuang, N.H., Chassy, B., Rautelin, H., Makela, P.H., Salminen, S., et al. (1996). Lactobacilli and bacteremia in southern Finland. Clinical Infectious Diseases, 22, 564-566.

    Schaafsma, G., Meuling, W.J., van Dokkum, W., & Bouley, C. (1998). Effects of a milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers. European Journal of Clinical Nutrition, 52, 436-440.

    Schulz, V., Hansel, R., & Tyler, V.E. (1998). Rational phytotherapy: A physician's guide to herbal medicine (3rd ed.) (T.C. Telger, Trans.). Berlin, Germany: Springer.

    Shils, M., Olson, A., & Shilke, M. (1994). Modern nutrition in health and disease (8th ed.). Philadelphia: Lea and Febiger.

    Shiomi, M., Sasaki, K., Murofushi, M., & Aibara, K. (1982). Antitumor activity in mice of orally administered polysaccharide from kefir grain. Japanese Journal of Medical Science and Biology, 35(2), 75-80.

    Sigurjonsdottir, H.A., Ragnarsson, J., Franzson, L., & Sigurdsson, G. (1995). Is blood pressure commonly raised by moderate consumption of licorice? Journal of Human Hypertension, 9, 345-348.

    Skolnick, A.A. (1996). Scientific verdict still out on DHEA. JAMA, 276, 1365-1367.

    Smolinske, S.C. (1999). Dietary supplement-drug interactions. Journal of American Medical Women's Association, 54, 191-192, 195.

    Soleas, G.J., Diamandis, E.P., & Goldberg, D.M. (1997). Resveratrol: A molecule whose time has come? And gone? Clinical Biochemistry, 30, 91-113.

    Sotaniemi, E.A., Haapakoski, E., & Rautio, A. (1995). Ginseng therapy in non-insulin dependent diabetic patients. Diabetes Care, 18, 1373-1375.

    Sparber, A., Bauer, L., Curt, G., Eisenberg, D., Levin, T., Parks, S., et al. (2000). Use of complementary medicine by adult patients participating in cancer clinical trials. Oncology Nursing Forum, 27, 623-630.

    Sparber, A., & Wootton, J.C. (2001). Surveys of complementary and alternative medicine: Part II. Use of alternative and complementary cancer therapies. Journal of Alternative and Complementary Medicine, 7, 281-287.

    Spielholz, C., Golde, D.W., Houghton, A.N., Nualart, F., & Vera, J.C. (1997). Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells. Cancer Research, 57, 2529-2537.

    Tyler, V.E. (1993). The honest herbal: A sensible guide to the use of herbs and related remedies (3rd ed.). Binghamton, NY: Pharmaceutical Products Press.

    Tyler, V.E. (1994). Herbs of choice: The therapeutic use of phytomedicinals. Binghamton, NY: Pharmaceutical Products Press.

    Tynkkynen, S., Singh, K.V., & Varmanen, P. (1998). Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. International Journal of Food Microbiology, 41, 195-204.

    U.S. Department of Agriculture. (1995). Nutrition and your health: Dietary guidelines for Americans (4th ed.). Washington, DC: U.S. Government Printing Office.

    van Vollenhoven, R.F. (2000). Dehydroepiandrosterone in systemic lupus erythematosus. Rheumatic Disease Clinics of North America, 26, 349-362.

    van Weerden, W.M., van Kreuningen, A., Elissen, N.M., de Jong, F.H., van Steenbrugge, G.J., & Schroder, F.H. (1992). Effects of adrenal androgens on the transplantable human prostate tumor PC-82. Endocrinology, 131, 2909-2913.

    Vera, J.C., Rivas, C.I., & Zhang, R.H. (1998). Colony-stimulating factors signal for increased transport of vitamin C in human host defense cells. Blood, 91, 2536-2546.

    Vera, J.C., Rivas, C.I., Zhang, R.H., Furber, C.M., & Golde, D.W. (1994). Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid. Blood, 84, 1628-1634.

    Vuksan, V., Sievenpiper, J.L., Koo, V.Y., Francis, T., Beljan-Zdravkovic, U., Xu, Z., et al. (2000). American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Archives of Internal Medicine, 160, 1009-1013.

    Vuksan, V., Stavro, M.P., Sievenpiper, J.L., Beljan-Zdravkovic, U., Leiter, L.A., Josse, R.G., et al. (2000). Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care, 23, 1221-1226.

    Watanabe, H., Kakihana, M., Ohtsuka, S., & Sugishita, Y. (1997). Randomized, double-blind, placebo-controlled study of supplemental vitamin E on attenuation of the development of nitrate tolerance. Circulation, 96, 2545-2550.

    Weber, B., Lewicka, S., Deuschle, M., Colla, M., & Heuser, I. (2000). Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology, 25, 765-771.

    White, J.D. (2002). Complementary and alternative medicine research: A National Cancer Institute perspective. Seminars in Oncology, 29, 546-551.

    Yun, J., Tomida, A., Nagata, K., & Tsuruo, T. (1995). Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II. Oncology Research, 7, 583-590.

    Zhu, W., Zhang, J.S., & Young, C.Y. (2001). Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP. Carcinogenesis, 22, 1399-1403