Fatigue and Depression in Patients With Lymphoma Undergoing Autologous Peripheral Blood Stem Cell Transplantation

Majeda Mohammad

Ann M. Berger

Lynne A. Farr

Martha J. Foxall

Barbara Friesth

Elizabeth Schreiner

ONF 2004, 31(5), 937-944. DOI: 10.1188/04.ONF.937-944

Purpose/Objectives: To describe the patterns of depression and fatigue, including its dimensions, and the relationship between these two variables in patients with lymphoma undergoing autologous peripheral blood stem cell transplantation (PBSCT).

Jump to a section


    Aaronson, L.S., Teel, C.S., Cassmeyer, V., Neuberger, G.B., Pallikkathayil, L., Pierce, J., et al. (1999). Defining and measuring fatigue. Image—The Journal of Nursing Scholarship, 31, 45-50.

    Andrykowski, M.A., Curran, S.L., & Lightner, R. (1998). Off-treatment fatigue in breast cancer survivors: A controlled comparison. Journal of Behavioral Medicine, 21(1), 1-18.

    Berger, A. (2001). Factors influencing cancer-related fatigue: Implications for research and practice. Home Health Care Consultant, 8(5), 28-36.

    Berger, A.M. (1998). Patterns of fatigue and activity and rest during adjuvant breast cancer chemotherapy. Oncology Nursing Forum, 25, 51-62.

    Bottomley, A. (1998). Anxiety and the adult cancer patient. European Journal of Cancer Care (English Language Edition), 7, 217-224.

    Bottomley, A. (1998b). Depression in cancer patients: A literature review. European Journal of Cancer Care (English Language Edition), 7, 181-191.

    Cella, D. (1997). The Functional Assessment of Cancer Therapy-Anemia (FACT-An) Scale: A new tool for the assessment of outcomes in cancer anemia and fatigue. Seminars in Oncology, 34(3, Suppl. 2), 13-19.

    Cella, D., Lai, J.S., Chang, C.H., Peterman, A., & Slavin, M. (2002). Fatigue in cancer patients compared with fatigue in the general United States population. Cancer, 94, 528-538.

    Cella, D., Peterman, A., Passik, S., Jacobsen, P., & Breitbart, W. (1998). Progress toward guidelines for the management of fatigue. Oncology (Huntington), 12, 369-377.

    Curt, G.A. (2000). The impact of fatigue on patients with cancer: Overview of FATIGUE 1 and 2. Oncologist, 5(Suppl. 2), 9-12.

    Curt, G.A., Breitbart, W., Cella, D., Groopman, J.E., Horning, S.J., Itri, L.M., et al. (2000). Impact of cancer-related fatigue on the lives of patients: New findings from the Fatigue Coalition. Oncologist, 5, 353-360.

    Dean, G.E. (2002). Circadian rhythms and the experience of fatigue in women before and after surgery for breast cancer. Unpublished doctoral dissertation, University of California Los Angeles, Los Angeles.

    Dean, G.E., Sarna, L.P., & Grant, M.M. (2001). Circadian rhythms and the experience of fatigue in women before and after surgery for breast cancer [Abstract 121]. Oncology Nursing Forum, 28(2, Suppl.), 343.

    Dodd, M., Janson, S., Facione, N., Faucett, J., Froelicher, E.S., Humphreys, J., et al. (2001). Advancing the science of symptom management. Journal of Advanced Nursing, 33, 668-676.

    Gaston-Johansson, F., Fall-Dickson, J.M., Bakos, A.B., & Kennedy, M.J. (1999). Fatigue, pain, and depression in pre-autotransplant breast cancer patients. Cancer Practice, 7, 240-247.

    Gaston-Johansson, F., & Foxall, M. (1996). Psychological correlates of quality of life across the autologous bone marrow transplant experience. Cancer Nursing, 19, 170-176.

    Gaston-Johansson, F., Franco, T., & Zimmerman, L. (1992). Pain and psychological distress in patients undergoing autologous bone marrow transplantation. Oncology Nursing Forum, 19, 41-48.

    Gaston-Johansson, F., Ohly, K.V., Fall-Dickson, J.M., Nanda, J.P., & Kennedy, M.J. (1999). Pain, psychological distress, health status, and coping in patients with breast cancer scheduled for autotransplantation. Oncology Nursing Forum, 26, 1337-1345.

    Glaus, A. (1993). Assessment of fatigue in cancer and non-cancer patients and in healthy individuals. Supportive Care in Cancer, 1, 305-315.

    Hann, D.M., Garovoy, N., Finkelstein, B., Jacobsen, P.B., Azzarello, L.M., & Fields, K.K. (1999). Fatigue and quality of life in breast cancer patients undergoing autologous stem cell transplantation: A longitudinal comparative study. Journal of Pain and Symptom Management, 17, 311-319.

    Hjermstad, M.J., Loge, J.H., Evensen, S.A., Kvaloy, S.O., Fayers, P.M., & Kaasa, S. (1999). The course of anxiety and depression during the first year after allogeneic or autologous stem cell transplantation. Bone Marrow Transplantation, 24, 1219-1228.

    Holley, S. (2000). Cancer-related fatigue: Suffering a different fatigue. Cancer Practice, 8, 87-95.

    Ibbotson, T., Maguire, P., Selby, P., Priestman, T., & Wallace, L. (1994). Screening for anxiety and depression in cancer patients: The effects of disease and treatment. European Journal of Cancer, 30A(1), 37-40.

    International Bone Marrow Transplant Registry/Autologous Blood and Bone Marrow Transplant Registry. (2002, February). Report on state of the art in blood and marrow transplantation. International Bone Marrow Transplant Registry/Autologous Blood and Marrow Transplant Registry Newsletter, 9(1), 4-11.

    Irvine, D., Vincent, L., Bubela, N., Thompson, L., & Graydon, J. (1991). A critical appraisal of the research literature investigating fatigue in the individual with cancer. Cancer Nursing, 14, 188-199.

    Irvine, D., Vincent, L., Graydon, J.E., Bubela, N., & Thompson, L. (1994). The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy. A comparison with the fatigue experienced by healthy individuals. Cancer Nursing, 17, 367-378.

    Jemal, A., Tiwari, R.C., Murray, T., Ghafoor, A., Samuels, A., Ward, E., et al. (2004). Cancer statistics, 2004. CA: A Cancer Journal for Clinicians, 54, 8-29.

    Knobel, H., Loge, J.H., Nordoy, T., Kolstad, A.L., Espevik, T., Kvaloy, S., et al. (2000). High level of fatigue in lymphoma patients treated with high dose therapy. Journal of Pain and Symptom Management, 19, 446-456.

    Leigh, S., Wilson, K., Burns, R., & Clark, R. (1995). Psychosocial morbidity in bone marrow transplant recipients: A prospective study. Bone Marrow Transplantation, 16, 635-640.

    Levenson, J.L., Hamer, R.M., & Rossiter, L.F. (1990). Relation of psychopathology in general medical inpatients to use and cost of services. American Journal of Psychiatry, 147, 1498-1503.

    McQuellon, R.P., Russell, G.B., Rambo, T.D., Craven, B.L., Radford, J., Perry, J.J., et al. (1998). Quality of life and psychological distress of bone marrow transplant recipients: The ‘time trajectory' to recovery over the first year. Bone Marrow Transplantation, 21, 477-486.

    Mock, V., Dow, K.H., Meares, C.J., Grimm, P.M., Dienemann, J.A., Hais-field-Wolfe, M.E., et al. (1997). Effects of exercise on fatigue, physical functioning, and emotional distress during radiation therapy for breast cancer. Oncology Nursing Forum, 24, 991-1000.

    Molassiotis, A., Boughton, B.J., Burgoyne, T., & van den Akker, O.B. (1995). Comparison of the overall quality of life in 50 long-term survivors of autologous and allogeneic bone marrow transplantation. Journal of Advanced Nursing, 22, 509-516.

    Molassiotis, A., & Morris, P.J. (1999). Quality of life in patients with chronic myeloid leukemia after unrelated donor bone marrow transplant. Cancer Nursing, 22, 340-349.

    Nail, L.M. (2002). Fatigue in patients with cancer. Oncology Nursing Forum, 29, 537-546.

    Nail, L.M., & King, K.B. (1987). Fatigue. Seminars in Oncology Nursing, 3, 257-262.

    Okun, A., Stein, R.E., Bauman, L.J., & Silver, E.J. (1996). Content validity of the Psychiatric Symptom Index, CES-Depression Scale, and State-Trait Anxiety Inventory from the perspective of DSM-IV. Psychological Reports, 79(3, Pt. 1), 1059-1069.

    Pickard-Holly, S. (1991). Fatigue in cancer patients: A descriptive study. Cancer Nursing, 14, 13-19.

    Piper, B.F. (1993). Fatigue. In V. Carrieri-Kohlman, A.M. Lindsey, & C. West (Eds.), Pathophysiological phenomena in nursing: Human responses to illness (2nd ed., pp. 279-302). Philadelphia: Saunders.

    Piper, B.F. (1998). Fatigue. In M. Ropka & A. Williams (Eds.), HIV nursing and symptom management (pp. 449-471). Sudbury, MA: Jones and Bartlett.

    Piper, B.F., Dibble, S.L., Dodd, M.J., Weiss, M.C., Slaughter, R.E., & Paul, S.M. (1998). The revised Piper Fatigue Scale: Psychometric evaluation in women with breast cancer. Oncology Nursing Forum, 25, 677-684.

    Piper, B.F., Lindsey, A.M., & Dodd, M. (1987). Fatigue mechanisms in cancer patients: Developing nursing theory. Oncology Nursing Forum, 14, 17-23.

    Piper, B.F., Lindsey, A.M., Dodd, M.J., Ferketich, S., Paul, S.M., & Weller, S. (1989). The development of an instrument to measure the subjective dimension of fatigue. In S.G. Funk, E.M. Tournquist, M.T. Champagne, L.A. Copp, & R.A. Weise (Eds.), Key aspects of comfort: Management of pain, fatigue, and nausea (pp. 199-208). New York: Springer.

    Pirl, W.F., & Roth, A.J. (1999). Diagnosis and treatment of depression in cancer patients. Oncology, 13, 1293-1301.

    Radloff, L.S. (1977). The CES-D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385-401.

    Ream, E., & Richardson, A. (1996). Fatigue: A concept analysis. International Journal of Nursing Studies, 33, 519-529.

    Redeker, N.S., Lev, E.L., & Ruggiero, J. (2000). Insomnia, fatigue, anxiety, depression, and quality of life of cancer patients undergoing chemotherapy. Scholarly Inquiry for Nursing Practice, 14, 275-290.

    Richardson, A. (1995). Fatigue in cancer patients: A review of the literature. European Journal of Cancer Care (English Language Edition), 4, 20-32.

    Richardson, A., Ream, E., & Wilson-Barnett, J. (1998). Fatigue in patients receiving chemotherapy: Patterns of change. Cancer Nursing, 21, 17-30.

    Schmit-Pokorny, K., Franco, T., Frappier, B., & Vyhlidal, R.C. (2003). The cooperative care model: An innovative approach to deliver blood and marrow stem cell transplant care. Clinical Journal of Oncology Nursing, 7, 509-514, 556.

    Schulz-Kindermann, F., Hennings, U., Ramm, G., Zander, A.R., & Hasenbring, M. (2002). The role of biomedical and psychosocial factors for the prediction of pain and distress in patients undergoing high-dose therapy and BMT/PBSCT. Bone Marrow Transplantation, 29, 341-351.

    Stone, P., Richardson, A., Ream, E., Smith, A.G., Kerr, D.J., & Kearney, N. (2000). Cancer-related fatigue: Inevitable, unimportant, and untreatable? Results of a multi-centre patient survey. Cancer Fatigue Forum. Annals of Oncology, 11, 971-975.

    Syrjala, K.L., Chapko, M.K., Vitaliano, P.P., Cummings, C., & Sullivan, K.M. (1993). Recovery after allogeneic marrow transplantation: Prospective study of predictors of long-term physical and psychosocial functioning. Bone Marrow Transplantation, 11, 319-327.

    Vahle, V.J., Andresen, E.M., & Hagglund, K.J. (2000). Depression measures in outcomes research. Archives of Physical Medicine and Rehabilitation, 81(12, Suppl. 2), S53-S62.

    Valentine, A.D., & Meyers, C.A. (2001). Cognitive and mood disturbance as causes and symptoms of fatigue in cancer patients. Cancer, 92(Suppl. 6), 1694-1698.

    Visser, M.R., & Smets, E.M. (1998). Fatigue, depression, and quality of life in cancer patients: How are they related? Supportive Care in Cancer, 6, 101-108.

    Winningham, M.L., & Barton-Burke, M. (2000). Fatigue in cancer: A multidimensional approach. Sudbury, MA: Jones and Bartlett.

    Winningham, M.L., Nail, L.M., Burke, M.B., Brophy, L., Cimprich, B., Jones, L., et al. (1994). Fatigue and the cancer experience: The state of the knowledge. Oncology Nursing Forum, 21, 23-36.

    Wolcott, D.L., Fawzy, F.I., & Wellisch, D.K. (1986). Psychiatric aspects of bone marrow transplantation: A review and current issues. Psychiatric Medicine, 4, 299-317.