Oncology nurse navigators (ONNs) help address barriers that would affect the patient’s ability to receive timely and quality cancer care and bridge gaps from the ambulatory to acute settings by reinforcing the treatment plan. For patients with acute myeloid leukemia, caregivers and medical teams are valuable resources when navigating the complexities of the healthcare environment. Developing ONN roles to manage transitions from acute to ambulatory care supports patients and organizations, and offers patients emotional support, education, and solutions to barriers of care.