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Manusirivithaya, S., Sripramote, M., Tangjitgamol, S., Sheanakul, C., Leelahakorn, S., Thavaramara, T., et al. (2004). Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin. International Journal of Gynecologic Cancer, 14, 1063-1069.
To determine the potential antiemetic effect of ginger in cisplatin-induced emesis
Intervention Characteristics/Basic Study Process
Patients were randomized to one of two groups. In regimen A, patients received 1 g of ginger per day for five days starting on the first day of chemotherapy. In regimen B, patients received a placebo on day one and metoclopramide on days two through five.
Sample Characteristics
The study consisted of 48 patients.
All patients were female.
All patients were being treated for gynecologic cancers and were receiving cisplatin chemotherapy.
Setting
The study was conducted in Bangkok, Thailand.
Measurement Instruments/Methods
Investigators assessed nausea and vomiting on day one. On days 2-5, patients recorded the presence and intensity of emetic episodes on diary cards.
Results
In regimen A, no effect was found in acute or delayed treatment. In regimen B, ginger had the same control as 40 mg metoclopramide for delayed nausea.
Limitations
The sample size was small.
Comparing antiemetics was difficult because the study did not use 5-HT3 antiemetics.