Gastrointestinal and Neuropsychological Symptoms Are Associated With Distinct Vomiting Profiles in Patients Receiving Chemotherapy

Komal P. Singh

Bruce A. Cooper

Steven M. Paul

Kathryn Ruddy

Amrit B. Singh

Jun Chen

Keenan A. Pituch

Tom E. Grys

Parminder Singh

Felipe Batalini

Marilyn J. Hammer

Jon D. Levine

Christine Miaskowski

cancer, chemotherapy, latent class analysis, nausea, vomiting
ONF 2024, 51(4), 361-380. DOI: 10.1188/24.ONF.361-380

Objectives: To identify subgroups of patients with distinct chemotherapy-induced vomiting (CIV) profiles; determine how these subgroups differ on several demographic, clinical, and symptom characteristics; and evaluate factors associated with chemotherapy-induced nausea and CIV profiles.

Sample & Setting: Adult patients (N = 1,338) receiving cancer chemotherapy.

Methods & Variables: Data were collected on demographic, clinical, and symptom characteristics. Differences among subgroups of patients with distinct CIV profiles were evaluated using parametric and nonparametric tests.

Results: Three CIV profiles (None, Decreasing, and Increasing) were identified. Compared with the None class, Decreasing and Increasing classes were more likely to have lower household income and a higher comorbidity burden, as well as to report higher rates of dry mouth, nausea, diarrhea, depression, anxiety, sleep disturbance, morning fatigue, and pain interference.

Implications for Nursing: Clinicians need to assess common and distinct risk factors for CIV and chemotherapy-induced nausea.

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