Supportive Care

Hypophysitis: Nursing Management of Immune-Related Adverse Events

Adrienne Vazquez

immunotherapy, hypophysitis, steroids, pituitary gland, immune-related adverse events
CJON 2017, 21(2), 154-156. DOI: 10.1188/17.CJON.154-156

Immunotherapy can treat cancer and prevent future cancer relapse by enhancing the body's immune system. With novel immunotherapeutic agents like checkpoint inhibitors come unique immune-related adverse events. Hypophysitis, one of the lesser known immune-related complications, may be observed in patients receiving checkpoint inhibitors. Although the acute symptoms of immune-related hypophysitis may be managed with attentive monitoring and high-dose corticosteroids, lifelong hormone substitution therapy may be warranted. Oncology nurses are responsible for educating themselves and their patients on the complications of immunotherapy.


  • Early identification and treatment of hypophysitis is important in the management of patients receiving immunotherapy.
  • Oncology nurses should educate themselves and their patients on the signs of hypophysitis.
  • A thorough baseline history and physical examination are required of every patient receiving immunotherapy.
Members Only
Not a current ONS member or journal subscriber?

Purchase This Article

Receive a PDF to download and print.