Fatigue is a commonly reported symptom of patients who have undergone hematopoietic stem cell transplantation (HSCT). Fatigue in the HSCT recipient has multiple possible causes, including deconditioning, anemia, and medications. Regardless of the cause, fatigue impacts patients' well-being, ability to reintegrate into their normal lifestyle, physical recovery from transplantation, and overall symptom management. The authors discuss the current evidence regarding exercise for the management of fatigue in this population and lay the groundwork for developing an evidence-based intervention.