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Oral Anticancer Agents

Article

Oral Agents for Cancer: Safety Challenges and Recommendations

Theresa Rudnitzki
Diana McMahon
CJON 2015, 19(3), 41-46 DOI: 10.1188/15.S1.CJON.41-46
Background: The lack of knowledge and standardization of safety practices related to prescribing, dispensing, administering, and monitoring oral agents for cancer (OACs) has created significant safety challenges for patients and healthcare providers. Problems identified with the use of OACs include...
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Factors Influencing Oral Adherence: Qualitative Metasummary and Triangulation With Quantitative Evidence

Margaret Irwin
Lee Ann Johnson
CJON 2015, 19(3), 6-30 DOI: 10.1188/15.S1.CJON.6-30
Background: Concern about adherence to oral agents among patients with cancer has grown as more oral agents are being used for cancer treatment. Knowledge of common factors that facilitate or inhibit adherence to oral medication regimens can be beneficial to clinicians in identifying patients at...
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Ibrutinib: A New Targeted Therapy for Hematologic Cancers

Caroline R. Smithson
Susan M. Schneider
CJON 2015, 19(3), E47-E51 DOI: 10.1188/15.CJON.E47-E51
Background: Hematologic cancers can occur from the overactivity of Bruton’s tyrosine kinase, a proto-oncogene in blood cell maturation. Ibrutinib, a new oral targeted therapy drug, is the first agent that binds to the Bruton’s tyrosine kinases and inhibits overgrowth of B cells. In blocking this...
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Treatment With Oral Anticancer Agents: Symptom Severity and Attribution, and Interference With Comorbidity Management

Barbara A. Given
Charles W. Given
Atreyee Majumder
ONF 2015, 42(1), 80-88 DOI: 10.1188/15.ONF.42-01P
Purpose/Objectives: To evaluate the prevalence, severity, and attribution of symptoms, as well as the interference with management of comorbidities, in patients who have been prescribed oral anticancer agents (OAs). Design: Descriptive exploratory study. Setting: A comprehensive cancer center and...
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Management of Steroid-Induced Hyperglycemia in Hospitalized Patients With Cancer: A Review

Veronica J. Brady
Deanna Grimes
Terri Armstrong
Geri LoBiondo-Wood
ONF 2014, 41(6), E355-E365 DOI: 10.1188/14.ONF.E355-E365
Problem Identification: Glucocorticoids are prescribed for hospitalized patients with cancer for a variety of reasons, including cerebral edema, treatment and prevention of nausea, and as part of cancer treatment regimens. Glucocorticoids are known to cause hyperglycemia. The purpose of this study...
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