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Hypersensitivity Reaction

CNE Article

Hypersensitivity Reactions: Priming Practice Change to Reduce Incidence in First-Dose Rituximab Treatment

Carissa Laudati
Caroline Clark
Andrea Knezevic
Zhigang Zhang
Margaret Barton-Burke
CJON 2018, 22(4), 407-414 DOI: 10.1188/18.CJON.407-414
Background: Strategies to reduce hypersensitivity reaction (HSR) incidence with rituximab include premedications and slow titration. Literature is lacking on the priming method used when preparing rituximab IV lines and the potential impact on HSR incidence. Objectives: The primary objective is to...
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CNE Article
Online Exclusive Article

Asparaginase Toxicities: Identification and Management in Patients With Acute Lymphoblastic Leukemia

Van Thu Huynh
Sharon Bergeron
CJON 2017, 21(5), E248-E259 DOI: 10.1188/17.CJON.E248-E259
Background: Acute lymphoblastic leukemia (ALL) is a common cancer in children, and outcomes have greatly improved because of the refinement of multiagent chemotherapy regimens that include intensified asparaginase therapy. Asparaginase, a cornerstone of modern pediatric chemotherapy regimens for...
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CNE Article

Self-Administered Premedication: Improving Taxane Chemotherapy Treatment

Kristin Roper
Mary Lou Siefert
Frances Fuller
Diane Lucier
Donna L. Berry
CJON 2017, 21(2), 234-239 DOI: 10.1188/17.CJON.234-239
Background: Patients receiving taxane therapy are at risk for hypersensitivity reactions without appropriate premedication management. Patients must understand the importance of taking premedications as prescribed to prevent reactions. Objectives: The objectives of this study were to implement and...
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Oncology Essentials

Benefits and Risks of Fosaprepitant in Patients Receiving Emetogenic Regimens

Wendy Pritchett
Karen Kinsley
CJON 2016, 20(5), 555-556 DOI: 10.1188/16.CJON.555-556
Fosaprepitant dimeglumine (Emend IV®) is an IV antiemetic that may be beneficial to patients receiving highly emetogenic regimens. Aprepitant (Emend®) is an oral medication that is administered for three consecutive days, whereas fosaprepitant is a single-dose IV medication that is administered on...
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Safety

Nursing Care of Patients Undergoing Chemotherapy Desensitization: Part I

Patricia Jakel
Cynthia Carsten
Melinda Braskett
Arvie Carino
CJON 2016, 20(1), 29-32 DOI: 10.1188/16.CJON.29-32
Hypersensitivity reactions to chemotherapeutic agents can cause the discontinuation of first-line therapies. Chemotherapy desensitization is a safe, but labor-intensive, process to administer these important medications. A desensitization protocol can enable a patient to receive the entire target...
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