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CNE Article

Checkpoint Inhibitors: Common Immune-Related Adverse Events and Their Management

RuthAnn Gordon
Mary Kate Kasler
Kristen Stasi
Yelena Shames
Mimma Errante
Kathryn Ciccolini
Anna Skripnik Lucas
Pam Raasch
Erica Fischer-Cartlidge
CJON 2017, 21(2), 45-52 DOI: 10.1188/17.CJON.S2.45-52
Background: Immunotherapy, specifically the use of checkpoint inhibitors, offers patients with cancer an alternative to chemotherapy, targeting different pathways to destroy cancer cells. The side effects of immunotherapies, as well as their impact on normal tissue, need to be assessed and managed...
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Online Exclusive Article

Diarrhea in Multiple Myeloma: A Review of the Literature

Beth Faiman
CJON 2016, 20(4), E100-E105 DOI: 10.1188/16.CJON.E100-E105
Background: One of the most common and inadequately managed symptoms that patients with multiple myeloma (MM) experience as a result of cancer treatment is diarrhea. Diarrhea in patients with MM often is severe enough to warrant dose reduction, delays, or discontinuation of chemotherapy. Short-term...
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Clinical Challenges

Norovirus in Immunocompromised Patients

Jill Atmar
Ellen Mullen
ONF 2013, 40(5), 434-436 DOI: 10.1188/13.ONF.434-436
While undergoing a routine mammogram, Mrs. B, age 76 years and in good health, was found to have right axillary adenopathy. A core biopsy confirmed the diagnosis of follicular lymphoma and she was referred to an oncologist who recommended treatment with six cycles of bendamustine, mitoxantrone, and...
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Oncology 101

Treatment-Related Diarrhea in Patients With Cancer

Colleen Shaw
Loryn Taylor
CJON 2012, 16(4), 413-417 DOI: 10.1188/12.CJON.413-417
Diarrhea caused by chemotherapy or radiation in patients with cancer can cause dehydration, electrolyte imbalance, malnutrition, fluid depletion, and hospitalization. In severe cases, uncontrolled diarrhea can lead to therapy dose reductions or even death. Oncology professionals may simply assess...
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Oncology 101

Clostridium Difficile Infection in Patients With Cancer

Debra Winkeljohn
CJON 2011, 15(2), 215-217 DOI: 10.1188/11.CJON.215-217
Patients with cancer undergoing chemotherapy often have diarrhea, which may result from their treatment or Clostridium difficile infection (CDI). CDI diarrhea is an important diagnosis that can be missed if nurses are not vigilant in their assessments. Treatment for CDI diarrhea is different than...
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